David Ackerley's picture
Dr David Ackerley
Victoria University of Wellington
Senior Lecturer in Biotechnology
KK507, School of Biological Sciences, Victoria University, Kelburn Parade, Wellington 6140
04 463 5576
My research focuses on the discovery, engineering, and applications of useful bacterial enzymes. I am an Associate Investigator in the Maurice Wilkins Centre for Molecular Biodiscovery, and collaborate with scientists at the Auckland Cancer Society Research Centre on the use of nitroreductase enzymes to activate imaging compounds and prodrugs for anti-cancer gene therapy. I also study non-ribosomal peptide synthetases and phosphopantetheinyl transferases that play key roles in the synthesis of a range of bioactive products. I have developed a variety of methods to screen for these enzymes and to improve their activity by targeted mutagenesis and directed evolution.